Individual's Information
Generation I * Q is dominant allele and q is the recessive allele for SCD 1.) Female carrier of Sickle Cell Disease. Her genotype is Qq. 2.) Male carrier of Sickle Cell Disease. His genotype is Qq. 3.) Female Infected with Sickle Cell Disease. Her genotype is qq. 4.) Male carrier of Sickle Cell Disease. His genotype is Qq. Generation II 1.) Unaffected Female . Her Genotype is QQ. 2.) Male carrier of Sickle Cell Disease. His genotype is Qq. 3.) Female Infected with Sickle Cell Disease. Her genotype is qq. 4.) Unaffected Male. His Genotype is QQ. 5.) Unaffected Female . Her Genotype is QQ. 6.) Male carrier of Sickle Cell Disease. His genotype is Qq. 7.) Male Infected with Sickle Cell Disease. His genotype is qq. Generation III 1.) Unaffected Male. His Genotype is QQ. 2.) Unaffected Female . Her Genotype is QQ. 3.) Male carrier of Sickle Cell Disease. His genotype is Qq. 4.) Unaffected Female . Her Genotype is QQ. 5.) Female carrier of Sickle Cell Disease. Her genotype is Qq. 6.) Unaffected Male . His Genotype is QQ. |
Offspring Outcomes
Generation I
*qq (Infected with SCD) *Qq (Carrier of SCD) *QQ (Unaffected) (1+2) Both parents were carriers. Both of their genotypes were Qq. Their offspring have a 50% chance of being a carrier (Qq) 25% chance of being unaffected (QQ) or 25% chance of getting infected (qq). (3+4) The female parent has SCD with a genotype of qq. The father was a carrier with Qq. Their offspring have a 50% chance of being a carrier (Qq) or 50% chance of getting infected (qq). Generation II (1+2) The female parent is unaffected (QQ) while the male parent is a carrier (Qq). Their offspring will have a 50% chance of being unaffected (QQ), or 50% chance to being a carrier (Qq). (3+4) The female parent is infected with SCD (qq), while the male parent is unaffected (QQ). Their offspring will have a 100% chance of being a carrier (Qq) (5+6) The female is unaffected (qq) while the male is a carrier (Qq). Their offspring have a 50% chance of being unaffected, or 50% chance of being carrier. |
Future Predictions
*This Applies to Generation III only.
(1,2,4,6) If the unaffected male (QQ) were to have an offspring the chances are; If the Female is unaffected with SCD the offspring will be unaffected. If the female parent is a carrier (Qq) the offspring will have a 50% chance to be a carrier, or a 50% chance of being unaffected. If the female parent has SCD (qq) the offspring will have a 100% chance of being a carrier. (For unaffected female switch genders.)
(3+5) If the male carrier (Qq) were to have an offspring the chances are; if the Female is unaffected with SCD the offspring will be have a 50% chance to be a carrier and a 50% to be unaffected. If the female parent is a carrier (Qq) the offspring will have a 50% to be a carrier, 25% to be unaffected, and 25% to be infected. If the female parent has SCD (qq) the offspring will have a 50% chance to be a carrier, or a 50% chance to be infected. (For female carrier switch genders.)
(1,2,4,6) If the unaffected male (QQ) were to have an offspring the chances are; If the Female is unaffected with SCD the offspring will be unaffected. If the female parent is a carrier (Qq) the offspring will have a 50% chance to be a carrier, or a 50% chance of being unaffected. If the female parent has SCD (qq) the offspring will have a 100% chance of being a carrier. (For unaffected female switch genders.)
(3+5) If the male carrier (Qq) were to have an offspring the chances are; if the Female is unaffected with SCD the offspring will be have a 50% chance to be a carrier and a 50% to be unaffected. If the female parent is a carrier (Qq) the offspring will have a 50% to be a carrier, 25% to be unaffected, and 25% to be infected. If the female parent has SCD (qq) the offspring will have a 50% chance to be a carrier, or a 50% chance to be infected. (For female carrier switch genders.)
Questions
Question 1. How can a family pedigree be used when discussing your medical history with a doctor?
Answer). A family pedigree can be used to predict and diagnose the diseases like SCD. As the diseases like SCD are passed to offspring from their parents the family pedigree can help the physician to predict the possibility of the offspring being a carrier, have a disease, and or unaffected. It also helps the individuals in choosing their partners and minimize the possibility of transferring disease to their offspring. For example if have a 50% chance for an offspring to have SCD or a deadly disease it may be wise to think if having a child is a good idea.
Question 2. Under what conditions or inheritance can a pedigree predict with 100 percent certainty what the genotype of an offspring will be?
Answer. The pedigrees offer a probability in percentage like a 50% chance for an offspring to have SCD. This however does not mean that 1 out of every 2 offsprings will have SCD. Its like rolling a dice and a game of luck. If there is a 50% chance pick 3 numbers and roll the dice. However, in some cases a pedigree can determine the genotype with 100% certainty. There are three ways for this to happen. If both parents have the recessive disease, their offspring will have 100% chance of have the recessive genotype and have the disease. If both parents are unaffected, their offspring will have a 100% chance of not being a carrier or have the disease. If one parent has a disease and the other parent is unaffected, the offspring will have a 100% chance of being a carrier.
Answer). A family pedigree can be used to predict and diagnose the diseases like SCD. As the diseases like SCD are passed to offspring from their parents the family pedigree can help the physician to predict the possibility of the offspring being a carrier, have a disease, and or unaffected. It also helps the individuals in choosing their partners and minimize the possibility of transferring disease to their offspring. For example if have a 50% chance for an offspring to have SCD or a deadly disease it may be wise to think if having a child is a good idea.
Question 2. Under what conditions or inheritance can a pedigree predict with 100 percent certainty what the genotype of an offspring will be?
Answer. The pedigrees offer a probability in percentage like a 50% chance for an offspring to have SCD. This however does not mean that 1 out of every 2 offsprings will have SCD. Its like rolling a dice and a game of luck. If there is a 50% chance pick 3 numbers and roll the dice. However, in some cases a pedigree can determine the genotype with 100% certainty. There are three ways for this to happen. If both parents have the recessive disease, their offspring will have 100% chance of have the recessive genotype and have the disease. If both parents are unaffected, their offspring will have a 100% chance of not being a carrier or have the disease. If one parent has a disease and the other parent is unaffected, the offspring will have a 100% chance of being a carrier.